uric acid production - A New Gout Drug. Febuxostat wins marketing approval in the European Union
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A New Gout Drug. Febuxostat wins marketing approval in the European Union

It has taken a very long time for a major new gout drug to be developed and approved. Probably the best gout news in over 40 years, is that Febuxostat, which has been given the trade/brand name of Adenuric, has been approved by the European Medicines Agency for marketing in European Union (EU) countries.


At 120 mg it has reduced UA levels to the target of 6.0 mg/dL in over 60% of study patients. At 80 mg the numbers were around 51%. Allopurinol at a 300 mg dosage in most participants achieved this is 22% of study patients. Hence the excited buzz in rheumatology circles since these kinds of results became apparent in its trials. At or below 6.0 mg/dL gout is more likely to be cured or managed better.


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"My big toe was in horrible pain, so i went to emergency room. Dr diagnosed gout in my foot and gave me pain killers. I did some googling and found goutezol. I like that it's natural with no chemicals in it. Ive been taking it for about 6 months and so far no attack, and my doc confirmed lower uric acid in my blood. thank you!" Jeff, NY
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  IT'S NOT PERFECT In trials its success rate in reducing UA levels down to the important 6.0 mg/dL (357 mmol/??mol) level was not 100%. About 35% of trial patients did not achieve the target. This may have been partly because so many gout sufferers are not UA over-producers, the problem Febuxostat addresses, but under-excretors of uric acid.

Overview of Gout Gout is a systemic disease caused by the buildup of uric acid in the joints, causing inflammation, swelling, and pain. This condition can develop for two reasons. The liver may produce more uric acid than the body can excrete in the urine, or a diet of rich foods (e.g., red meat, cream sauces, red wine) puts more uric acid into the bloodstream than the kidneys can filter. In both cases, a condition called hyperuricemia results. Over time, the uric acid crystallizes and settles in the joint spaces, most commonly in the first metatarsal phalangeal joint of the big toe or in the ankle joint. Signs and Symptoms The most common symptoms of gout are inflammation, swelling, and tenderness in the joint of the first toe. Touching or moving it is intensely painful and patients often say it hurts to have as much as a bedsheet over the toe. Gout develops quickly and typically occurs in only one joint at a time. Symptoms may develop in two or three joints simultaneously, but this is rare. If widespread symptoms occur, the condition is probably not gout. Diagnosis The most reliable way to diagnose gout is to examine the joint fluid for uric acid crystals. This is done by drawing fluid from the joint with a needle and examining it under a polarized light microscope. Although the test is invasive, the results are definitive, and a positive result facilitates proper treatment and quick relief. Treatment Treatment for gout involves decreasing the amount of uric acid in the joint. If dietary habits are the cause, the patient's lifestyle must be changed to avoid the condition. Gout is readily corrected with patient cooperation, and it is usually not treated unless it occurs frequently. Colchicine is a common medication for treating acute gout attacks. If continuous medication is necessary, the two most common choices are probenecid and allopurinol. Prevention Alcohol and rich foods are primary contributors to excessive uric acid levels. Although some patients have a genetic predisposition to excessive uric acid production, most gout patients have normal kidneys and uncontrolled dietary habits. Prevention is the best defense against the disease. Many patients who suffer from gout continue to indulge, and suffer frequent attacks as a result. Although medication makes it possible to live with gout, the continued accumulation of uric acid in the joints eventually damages them, seriously inhibiting movement.

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It is recommended that NSAIDs or Colchicine are used along with Adenuric. This is because, as with Allopurinol, on a course of Febuxostat, there may be an initial increase in gout flares. If this happens you must battle through the attacks and continue taking Adenuric.

Hyperuricemia is when uric acid levels are too high and can lead to gout and kidney stones. Also, a recent study by doctors at John Hopkins University Hospital found that cognitive functions can be reduced if there is increased Uric Acid in the body. The research was carried out on just under 100 people between the ages of 65 - 92.

Gout can also be caused by certain medications, such as thiazide diuretic drugs, which are prescribed for heart failure and hypertension. Figures show that the majority of people who use this kind of drug acquired gout later in life. Other drugs that may contribute to a higher risk for gout are immunosuppressants (such as cyclosporine), low doses of aspirin, and pyrazinamide, an anti-tuberculosis agent. Gout is also strangely related to organ transplantation. Heart and liver transplants can heighten the risk, but perhaps it's a kidney transplant that poses the greater risk, since renal problems can prevent the elimination of uric acid from the body.

A condition called hyperuricemia is one of the causes of gout. This is when the body fails to eliminate excess amounts of uric acid. Some people are born with a genetic metabolic defect in which they not only produce extra uric acid, but they fail to excrete it efficiently as well. This is bad because excessive amounts of uric acid will lead to the formation of uric crystals, which will then become embedded in the joints and the tissue surrounding them. These crystals are also known as tophi, and they are the cause of joint inflammation and pain. Gout usually appears in the joint of the big toe, but it can also become manifest in joints in the ankles, feet, knees, wrists, hands, and elbows. Pictures of a gouty toe almost always show the same characteristics: swelling and redness, and as you can probably imagine, pain.

7. Finally, we also suggest cherries because they hold loads of fiber (to flush) and they also have been shown to reduce inflammations. This popular but effective alternative remedy for gout has been handed down for thousands of years. We suggest about 8 ounces of cherries per day.

Although gout is can be a hereditary condition where the body fails to process uric acid efficiently, you can help your body regain its balance by minimizing external factors that raise uric acid levels. One of the main factors that you can control to alleviate gout is to reduce the levels of purine rich foods consumed.

If you have severe kidney or liver problems Febuxostat is not recommended since it has not been tested in these patient groups. It is not recommended for people with heart disease or children.

3. Vitamin C or ascorbic acid has shown to be quite effective. While taken in high doses, vitamin C can decrease uric acid levels in the blood.

4. Folic acid has also been shown some benefits in various studies. About 600 mcg per day may inhibit xanthine oxidase, which is required for uric acid production.

It will also only be used in gout patients who have chronic hyperuricemia (high UA levels) and gout. So if you're a gout sufferer who lives in a European country that's a member of the EU, you can ask your doctor's opinion about whether Febuxostat is suitable for you.

A Two Hour Treatment that Works As Google has shown you, there are tons of studies that have been done on this painful disease. As a leading natural health company, we have sifted through all of it and put together a 100% guaranteed gout pain treatment that works in less than 2 hours. Though these seven tips are a great start, they are only half of our proven treatment plan.

They found that elevated levels of uric acid meant that people were more likely to have below average scores on cognitive function tests. So, not only can high uric acid levels lead to a painful gout attack, but can negatively effect your verbal and memory scores. More reason to find a gout free diet that will help to lower uric acid levels.

Uric acid is naturally produced by the body and is an antioxidant. During the metabolizing process it is dissolved in the blood stream and then excreted via the kidneys and intestines. However, too much can be a bad thing, leading to a situation within the body called hyperuricemia.

Whatever the case, simple tips and homeopathic remedies can be used to flush the uric acid naturally. Homeopathy and Gout Gout homeopathy remedies can provide pain relief during an attack. Many of the remedies are extremely simple and effective. In general, these tips will work to either flush the uric acid or neutralize the acid.

NB. The contents of this article contain medical information not medical advice. Please always discuss remedies with your doctor or other health care professional, before implementing any treatment.

Ouch! The remedy for your aching toe is an effective gout pain treatment. Though there is no known cure for gout yet, research is showing that a complete cure will be here soon. In the mean time, you can address your painful problem with gout homeopathy and simple lifestyle tips that many doctors are now recommending to their patients.

From obesity, we move to related causes of gout, specifically dietary and food habits. There are many types of food that have large amounts of purines, or substances that play a large role in uric acid production. It's kind of disturbing to find out that most foods that are rich in protein and fat also have a high purine content. But in today's fast-paced mode of life, this is just the kind of food that we're accustomed to eating! To further reduce the risk of acquiring gout, one should also refrain from taking in too much organ meats or sweetbread (including heart, kidney, and liver delicacies). Some seafoods, such as scallops, mackerel, and mussels are also dietary no-no's because these too are rich in purines. Intake of high-fat dairy foods should also be curtailed, including comfort foods like ice cream, butter, and cheese.

Noted possible side effects dizziness, drowsiness, diarrhoea, rashes, headaches, hypertension and liver function abnormalities - considered mild ones. In trials none of these side effects were reported in more than 3.5% of trial patients. The most common were liver function abnormalities.

This approval applies only to EU countries. Febuxostat has not yet been approved in the United States. If you are reading this from a non-EU country, or the US, you can check with your doctor to find out whether, or when, Febuxostat will be approved in your country.

 
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This article is Copyright 2005 by http://www.organicgreens.us, http://www.organicgreens.ca and Loring Windblad. This article may be freely copied and used on other web sites only if it is copied complete with all links and text, including the Authors Resource Box, intact and unchanged except for minor improvements.

What you may not know about diabetes ' the truth about insulin resistance. 92% of people with type 2 diabetes have insulin resistance. Get the facts ' go to your local diabetes agency or research it on the internet.

Tophi If you have tophi, it's heartening to know that Febuxostat has been shown to have success against tophi. Measured tophi areas reduced in many patients with tophi. The presence of tophi will be an additional factor in favour of a decision to prescribe Febuxostat (Adenuric).

Ensure that you are keeping your body sufficiently hydrated by drinking at minimum 6 - 8 eight ounce glasses of water. Dehydration will increase uric acid levels as without enough water uric acid will become more concentrated in the blood and the kidneys will struggle to expel it. By staying hydrated you will dilute the uric acid and the kidneys will have a easier time of the elimination process.

When purine is ingested the waste by-product is uric acid. Purine is found in many of our foods and in all proteins to a greater or lesser degree.

The worst offenders are red meats, offal, processed meats, some shellfish, yeast extracts, gravies and alcohol. All of these encourage uric acid production within the body.

John Mepham has lost track of the number of hours he has spent researching gout treatments. His best tip for curing gout naturally? Get to your ideal weight whatever the sacrifices may be. Learn more about natural gout treatment at www.gout-smashers-guide.com It's an e-book with an emphasis on natural gout treatment

Here are some gout homeopathy tips and simple remedies to try. 1. Maintain an ideal weight and drink plenty of water. Water can help you lose weight and also help the kidneys flush uric acid from the body. Dehydration breeds attacks. Drink at least 10-12 glasses of water a day.

Generally, Febuxostat has been more effective when UA levels are below 10.0 mg/dL (595 mmol/??mol). However, even if they have been above this level, it has reduced UA levels down to the target in about 40% of study patients at an 80 mg dosage, and by more at higher dosages.

Scientists are now beginning to explore the effects of anthocyanins and flavonoids on uric acid production. The Medical Universities are putting out more concrete evidence continually, concerning the health benefits associated with these Tart Cherries. Gout Cherry Juice is made from these Tart Cherries, and the comments from users are showing that the benefits drawn from the juice can relieve the pain and inflammation associated with gout, pleasing many people who are afflicted with the disease. It is always recommended to check with your doctor before discontinuing medication, or making large changes in your diet. For more information about Gout Diet?, feel free to visit us at: http://www.about-goat.info/Articles/Gout_Diet.php

Sticking to dietary goals while eating out can be very challenging. Many, even most, restaurants cater to people with special dietary needs ' just ask. And learn those restaurants which do not and avoid them.

Overview of Diabetes New to diabetes? Learn the basics ' check with your local diabetes clinic or research it on the internet. A key to diabetes management is maintaining a regular exercise program. Its never too late to start ' see below. Sticking to dietary goals while eating out also can be very challenging ' see comments below. 20 million Americans and Canadians have diabetes. Nearly 7 million don't know it. Type 2 diabetes usually develops slowly, and the symptoms often go unnoticed. Our son developed a puffiness to his face which we noticed right away because we saw him only a couple of times a year. He and his wife put it down to simple weight gain. After 2' years they finally snapped to there being something wrong and when he was finally checked out his diabetes was 'off the charts'. Fortunately, they caught it in time, but it should have been caught over a year earlier. Nearly 90 to 95% of all people with diabetes have type 2. Who gets it? Just about any body. Fat, skinny, regular build, it makes no difference; just about everyone can develop diabetes. Most at risk are people regardless of body build who live on a high intake of 'junk food'. Least at risk are people who eat a regular balanced diet.


About the author: Loring Windblad has studied nutrition and exercise for more than 40 years, is a published author and freelance writer.

Your uric acid levels will have to be high. If you have gout but normal or slightly raised uric acid levels as some do, it is unlikely to be prescribed.

A number of health problems have been shown to lead to gout. Certain cancers or diseases involving blood-manufacturing organs are specifically cited, such as lymphoma and leukemia. A skin disease called psoriasis has likewise been linked to the emergence of gout in a number of people. And over-exposure to lead does not only cause birth defects and blood poisoning, it can lead to gout as well. Another all too common health problem among many people, especially those in the West, is obesity. Being overweight can cause not only gout, but other diseases as well, including diabetes, hypertension, and other forms of arthritis.




Obesity is a major risk factor for diabetes. Obesity is not a guarantee you will develop diabetes and many obese persons never develop it, but persons who are obese

However, as science leads us to understanding our body more. Simple gout pain treatment remedies have been used since the time of kings (gout is known as the disease of kings) are one of the most effective ways to treat the arthritic pain.

The help of friends and family can make all the difference to someone with diabetes. Help for Diabetes, Gout and Other Disorders Check out these products, Native's Gift, Desert Promise, Bio88+, and see if there is something here for you. They are all 'Native and Natural' products, manufactured under strict quality control. In the case of Bio88+, a Greens product, it is manufactured in a government controlled University laboratory.

Gout Cherry Juice is made from Tart Cherries, which contain anthocyanins and flavonoids. These naturally occurring ingredients are what appears to be helping out the gout patients.

Diabetic meals can be healthy and savory. A key to diabetes management is maintaining a regular exercise program. Its never too late to start and you can do it with a simple walking program. Just walk 1 kilometer a day and over a period of a month build it up to two miles (3 kilometers) a day.

Check out these product testimonials and see what you think about what these products have accomplished in many other lives. Scroll to the bottom of the page and contact the people who gave these testimonials.

On the testimonials page below I am L. Windblad and my wife is J.D. Windblad. I have long-term gout (since 1977), damage from gout including numbness and pain in the feet, a prostate which had ceased functioning for the past 2 years, and in Jan 2004 I was diagnosed with a lazy thyroid. By the end of January my thyroid was functioning normally, by April I was noticing an improvement in prostate functioning and by mid-May it was definitely clear that not only was the pain gone but feeling was coming back into my feet. This is written in June 2004 and its all still getting better.

Grab a piece of paper because here is what you should know if you suffer from the 'big toe' arthritis. Gout is all about Uric Acid Gout has everything to deal with uric acid. Gout occurs when urate crystals gather on the affected joint. You will notice inflammation and intense pain during an attack. The uric acid crystal levels increase when your body is not able to flush the acid effectively. Uric acid can be always found in your body and is also found in many of the foods we eat.

Though natural health and natural remedies have often been viewed as taboo in western societies, many traditional doctors have now switched from synthetic pain killers and antinflamatories to good old fashion natural homeopathic treatments that were once viewed as quack.

6. Ouercetin has also been shown to have to have anti-inflammatory qualities. You should take this bioflavonoid along with bromelain at about the same amount.

And it may cause side effects of course. See the bottom of this article. Febuxostat (Adenuric) is not unfortunately a treatment for gout pain. It won't be used instead of NSAIDS like Indomethacin, Colchicine, and corticosteroids.

There are other stories of 'miracles' with these products and they will be posted as soon as they can be collected. What these products actually do is work to make your body function the way it is supposed to function, and they accomplish this at least in part by restoring your natural Ph balances.

Approval in one country does not mean approval in another, but the fact that the European Medicines Agency has approved it will carry weight when the medical authorities in other countries consider its approval.


You can find out more about relieving gout symptoms for good by signing up for our free newsletter.


One last thought, a gout free diet does not need to be boring many herbs and spices, and healthy options are available to make tasty and nutritious meals that won't aggravate your gout.


 
 
     
 
 





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Gout is a painful disease of the joints, which usually affects the big toe first in most people. It is caused by too much uric acid in the blood. Uric acid is formed by the breakdown of chemicals called purines, which can lead to high levels of uric acid and cause many problems such as joint swelling and kidney stones. Normally the uric acid is dissolved in the blood and passes out via the...


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